Virulence of Escherichia coli B2 isolates from meat and animals in a murine model of ascending urinary tract infection (UTI): evidence that UTI is a zoonosis

Lotte Jakobsen; Anette M Hammerum; Niels Frimodt-Møller

doi:10.1128/JCM.00281-10

Virulence of Escherichia coli B2 isolates from meat and animals in a murine model of ascending urinary tract infection (UTI): evidence that UTI is a zoonosis

J Clin Microbiol. 2010 Aug;48(8):2978-80. doi: 10.1128/JCM.00281-10. Epub 2010 Jun 2.

Authors

Lotte Jakobsen¹, Anette M Hammerum, Niels Frimodt-Møller

Affiliation

¹ National Center for Antimicrobials and Infection Control, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. lja@ssi.dk

Abstract

In vivo evidence of a connection between urinary tract infections (UTI) and foods is lacking. The virulence of 13 Escherichia coli B2 isolates from healthy animals and fresh meat was investigated in a murine model of ascending UTI. All isolates produced positive bladder cultures (10(2) to 10(7) CFU), and nine isolates produced positive kidney cultures (10(2) to 10(5) CFU).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chickens / microbiology*
Colony Count, Microbial
Disease Models, Animal
Escherichia coli / isolation & purification*
Escherichia coli / pathogenicity*
Escherichia coli Infections / microbiology*
Escherichia coli Infections / pathology
Female
Kidney / microbiology
Meat / microbiology*
Mice
Swine / microbiology*
Urinary Bladder / microbiology
Urinary Tract Infections / microbiology*
Urinary Tract Infections / pathology
Virulence