Adiponectin sparks an interest in calcium

Darren C Henstridge; Mark A Febbraio

doi:10.1016/j.cmet.2010.05.007

Adiponectin sparks an interest in calcium

Cell Metab. 2010 Jun 9;11(6):447-9. doi: 10.1016/j.cmet.2010.05.007.

Authors

Darren C Henstridge¹, Mark A Febbraio

Affiliation

¹ Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia.

PMID: 20519115
DOI: 10.1016/j.cmet.2010.05.007

Abstract

Adiponectin and its receptors, AdipoR1 and AdipoR2, regulate glucose and fatty acid metabolism via activation of AMP-activated protein kinase. Recent work in Nature (Iwabu et al., 2010) demonstrates that adiponectin induces a marked Ca(2+) influx in skeletal muscle via AdipoR1 to control mitochondrial biogenesis, reduce oxidative stress, and enhance endurance capacity.

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