Transfer hydrogenation in water: enantioselective, catalytic reduction of alpha-cyano and alpha-nitro substituted acetophenones

Org Lett. 2010 Jul 2;12(13):2893-5. doi: 10.1021/ol1008894.

Abstract

Catalytic reduction of alpha-substituted acetophenones under conditions involving asymmetric transfer hydrogenation in water is described. The reaction is conducted in water and open to air, and formic acid is used as reductant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetophenones / chemical synthesis*
  • Acetophenones / chemistry
  • Catalysis
  • Formates / chemistry
  • Hydrogenation
  • Iridium / chemistry*
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Oxidation-Reduction
  • Stereoisomerism
  • Water / chemistry*

Substances

  • Acetophenones
  • Formates
  • Organometallic Compounds
  • Water
  • formic acid
  • Iridium