Abstract
Purpose:
Radiation-induced olfactory neuroblastoma (ONB) is an uncommon neoplasm that is generally associated with a poor prognosis. We describe a new case of olfactory neuroblastoma in a patient previously treated for astrocytoma with holocranial radiotherapy 9 years ago.
Materials and methods:
We reviewed the medical records of four patients with radiation-induced olfactory neuroblastoma between 2001 and 2009.
Results:
This work supports the idea that ONB can be induced by radiation.
Conclusions:
As radiotherapy is a standard treatment in other tumors, clinicians must be aware of the possibility of a second tumor induced by radiation.
MeSH terms
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Adult
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Astrocytoma / radiotherapy*
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Brain Neoplasms / radiotherapy*
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Cobalt Radioisotopes / adverse effects*
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Combined Modality Therapy
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Cranial Irradiation / adverse effects*
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Esthesioneuroblastoma, Olfactory / diagnosis
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Esthesioneuroblastoma, Olfactory / etiology*
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Esthesioneuroblastoma, Olfactory / radiotherapy
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Esthesioneuroblastoma, Olfactory / surgery
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Female
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Frontal Lobe*
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Humans
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Image Processing, Computer-Assisted
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Magnetic Resonance Imaging
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Nasal Cavity*
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Neoplasms, Second Primary / diagnosis
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Neoplasms, Second Primary / etiology*
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Neoplasms, Second Primary / radiotherapy
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Neoplasms, Second Primary / surgery
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Nose Neoplasms / diagnosis
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Nose Neoplasms / etiology*
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Nose Neoplasms / radiotherapy
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Nose Neoplasms / surgery
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Paranasal Sinus Neoplasms / diagnosis
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Paranasal Sinus Neoplasms / etiology*
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Paranasal Sinus Neoplasms / radiotherapy
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Paranasal Sinus Neoplasms / surgery
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Radioisotope Teletherapy / adverse effects*
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Radiotherapy Planning, Computer-Assisted
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Radiotherapy, Adjuvant