Invasive aspergillosis after pandemic (H1N1) 2009

Emerg Infect Dis. 2010 Jun;16(6):971-3. doi: 10.3201/eid1606.100165.

Abstract

We report 2 patients with invasive aspergillosis after infection with pandemic (H1N1) 2009. Influenza viruses are known to cause immunologic defects and impair ciliary clearance. These defects, combined with high-dose corticosteroids prescribed during influenza-associated adult respiratory distress syndrome, may be novel risk factors predisposing otherwise immunocompetent patients to invasive aspergillosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / administration & dosage
  • Aspergillosis / drug therapy
  • Aspergillosis / etiology*
  • Aspergillosis / pathology
  • Aspergillus fumigatus*
  • Fatal Outcome
  • Glucocorticoids / administration & dosage
  • Humans
  • Immunocompetence
  • Influenza A Virus, H1N1 Subtype*
  • Influenza, Human / complications*
  • Influenza, Human / immunology
  • Influenza, Human / virology
  • Male
  • Methylprednisolone / administration & dosage
  • Middle Aged
  • Respiratory Distress Syndrome / drug therapy
  • Respiratory Distress Syndrome / etiology
  • Risk Factors
  • Time Factors

Substances

  • Antifungal Agents
  • Glucocorticoids
  • Methylprednisolone