Family distances as a measure of hidden consanguinity. A reappraisal

Hum Hered. 1991;41(1):12-6. doi: 10.1159/000153967.

Abstract

We compared the family distances of patients with autosomal recessive disorders with those of a random control group and a matched control group. Only in the great-grandparental generation were weak-significant differences found. We also found that the family distances of persons with an urban origin were significantly larger than those of persons with a rural origin. In our study, family distance seems to be a more powerful measure of hidden consanguinity than the parental distance.

MeSH terms

  • Chromosome Aberrations / genetics*
  • Chromosome Disorders
  • Consanguinity*
  • Female
  • Genes, Recessive*
  • Humans
  • Male
  • Netherlands
  • Pedigree
  • Prevalence
  • Random Allocation
  • Rural Population
  • Urban Population