Effect of chlorpromazine on the toxicity of doxorubicin in mice

H Shibata; I Maekawa; S Furusawa; H Kawauchi; Y Takayanagi; K Sasaki

Effect of chlorpromazine on the toxicity of doxorubicin in mice

Res Commun Chem Pathol Pharmacol. 1991 Mar;71(3):381-4.

Authors

H Shibata¹, I Maekawa, S Furusawa, H Kawauchi, Y Takayanagi, K Sasaki

Affiliation

¹ Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.

PMID: 2047578

Abstract

The effect of chlorpromazine (CPZ) on the toxicity of doxorubicin (DOX) were investigated in mice. CPZ significantly enhanced the acute toxicity and bone marrow toxicity induced by DOX. These results suggest the potentiation of DOX toxicity by CPZ is due to increase of sensitivity of mice to DOX.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Marrow / drug effects
Bone Marrow / pathology
Chlorpromazine / administration & dosage
Chlorpromazine / toxicity*
Doxorubicin / administration & dosage
Doxorubicin / toxicity*
Drug Resistance
Drug Synergism
Lethal Dose 50
Male
Membrane Lipids / metabolism
Mice

Substances

Membrane Lipids
Doxorubicin
Chlorpromazine