Biochemical activities of the derivatives of dehydrodicaffeic acid dilactone

J Antibiot (Tokyo). 1978 Feb;31(2):105-11. doi: 10.7164/antibiotics.31.105.

Abstract

Activities of derivatives of dehydrodicaffeic acid dilactone (DDCAD) to inhibit catechol-O-methyltransferase (COMT), cyclic AMP phosphodiesterase (PDE) and DOPA decarboxylase (DDC) were examined. Among those tested, 2,6-bis-(5',6'-dibromo-4'-hydroxy-3'-methoxyphenyl)-3,7-dioxabicyclo-[3,3,0]-octane 4,8-dione was found to be the strongest inhibitor of both COMT and PDE. There were no derivatives which showed a stronger inhibition against DDC than the original compound, DDCAD.

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
  • Animals
  • Aromatic Amino Acid Decarboxylase Inhibitors*
  • Caffeic Acids / pharmacology*
  • Catechol O-Methyltransferase Inhibitors*
  • Cinnamates / pharmacology*
  • In Vitro Techniques
  • Kinetics
  • Lactones / pharmacology
  • Magnesium / pharmacology
  • Mice
  • Structure-Activity Relationship

Substances

  • Aromatic Amino Acid Decarboxylase Inhibitors
  • Caffeic Acids
  • Catechol O-Methyltransferase Inhibitors
  • Cinnamates
  • Lactones
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Magnesium