Abstract
A straightforward, high-yielding, chemoenzymatic total synthesis of enantiopure (S)-Rivastigmine was developed using various omega-transaminases for the asymmetric amination of appropriate acetophenone precursors. Optimisation of the biotransformation allowed scale-up and the total synthesis of (S)-Rivastigmine.
MeSH terms
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Acetophenones / chemistry
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Bacteria / enzymology*
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Neuroprotective Agents / chemical synthesis*
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / metabolism
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Phenylcarbamates / chemical synthesis*
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Phenylcarbamates / chemistry
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Phenylcarbamates / metabolism
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Rivastigmine
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Stereoisomerism
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Transaminases / metabolism*
Substances
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Acetophenones
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Neuroprotective Agents
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Phenylcarbamates
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Transaminases
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Rivastigmine
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acetophenone