Abstract
Trifluoromethyl nitrones were obtained in high yields by condensation of various hydroxylamines with trifluoroacetaldehyde hydrate. The nucleophilic diastereoselective additions of organometallic reagents to these nitrones afforded the corresponding optically active trifluoroethyl hydroxylamines in good yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetaldehyde / analogs & derivatives*
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Acetaldehyde / chemistry
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Chlorofluorocarbons, Methane / chemistry*
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Hydroxylamine / chemistry*
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Nitrogen Oxides / chemistry*
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Optical Phenomena*
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Stereoisomerism
Substances
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Chlorofluorocarbons, Methane
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Nitrogen Oxides
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nitrones
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Hydroxylamine
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trifluoroacetaldehyde hydrate
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Acetaldehyde
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fluoroform