Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events

Virology. 2010 Jul 5;402(2):223-7. doi: 10.1016/j.virol.2010.03.048. Epub 2010 May 1.

Abstract

We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asia / epidemiology
  • Blood Donors
  • Cluster Analysis
  • Genotype
  • Geography
  • HIV Infections / epidemiology*
  • HIV Infections / virology
  • HIV-1 / classification*
  • HIV-1 / genetics
  • HIV-1 / isolation & purification*
  • Humans
  • Molecular Epidemiology
  • RNA, Viral / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • Risk Factors
  • Risk-Taking
  • Sequence Analysis, DNA
  • Sequence Homology
  • Substance Abuse, Intravenous
  • gag Gene Products, Human Immunodeficiency Virus / genetics

Substances

  • RNA, Viral
  • gag Gene Products, Human Immunodeficiency Virus