Tetherin: holding on and letting go

Cell. 2010 Apr 30;141(3):392-8. doi: 10.1016/j.cell.2010.04.022.

Abstract

Mammalian cells are equipped with so-called "restriction factors" that suppress virus replication and help to prevent virus transmission from one species to another. This Essay discusses the host restriction factor tetherin, which blocks the release of enveloped viruses like HIV-1, and the factors evolved by primate lentiviruses, such as Vpu and Nef, that antagonize tetherin's action.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / genetics
  • Antigens, CD / immunology
  • Antigens, CD / metabolism*
  • GPI-Linked Proteins
  • Gene Products, nef / metabolism
  • HIV-1 / metabolism*
  • Human Immunodeficiency Virus Proteins / metabolism
  • Humans
  • Lentivirus / genetics
  • Lentivirus Infections / drug therapy
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / immunology
  • Membrane Glycoproteins / metabolism*
  • Viral Regulatory and Accessory Proteins / metabolism

Substances

  • Antigens, CD
  • BST2 protein, human
  • GPI-Linked Proteins
  • Gene Products, nef
  • Human Immunodeficiency Virus Proteins
  • Membrane Glycoproteins
  • Viral Regulatory and Accessory Proteins
  • vpu protein, Human immunodeficiency virus 1