Polymorphisms in DNA damage response genes and head and neck cancer risk

Biomarkers. 2010 Aug;15(5):379-99. doi: 10.3109/13547501003797664.

Abstract

Background: Polymorphisms in DNA repair genes have been reported contributing factors in head and neck cancer risk but studies have shown conflicting results.

Objective: To clarify the impact of DNA repair gene polymorphisms in head and neck cancer risk.

Method: A meta-analysis including 30 case-control studies was performed.

Results: Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer.

Conclusion: Assessments of the effects of smoking, alcohol, human papillomavirus and race/ethnicity on the association between DNA repair gene polymorphisms and head and neck cancer are needed.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Case-Control Studies
  • Codon / genetics
  • DNA-Binding Proteins / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics
  • Head and Neck Neoplasms / genetics*
  • Humans
  • Polymorphism, Genetic*
  • X-ray Repair Cross Complementing Protein 1

Substances

  • Codon
  • DNA-Binding Proteins
  • X-ray Repair Cross Complementing Protein 1
  • XRCC1 protein, human
  • xeroderma pigmentosum group F protein