Using graphene to protect DNA from cleavage during cellular delivery

Chem Commun (Camb). 2010 May 14;46(18):3116-8. doi: 10.1039/b926893f. Epub 2010 Mar 29.

Abstract

We have proved that functionalized nanoscale graphene oxide can protect oligonucleotides from enzymatic cleavage and efficiently deliver oligonucleotides into cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon / chemistry*
  • Carbon / metabolism
  • Cell Survival
  • HeLa Cells
  • Humans
  • Oligonucleotides / administration & dosage*
  • Oligonucleotides / chemistry
  • Oligonucleotides / metabolism

Substances

  • Oligonucleotides
  • Carbon