Several studies have examined the neural effects of working memory practice, but due to different task demands, diverse patterns of neural changes have been reported. In the present study, we examined neural effects of practice using a task with different working memory demands within a single practice paradigm. Fifteen adults practiced during 6weeks with a task that required maintenance and manipulation of information under low and high working memory loads. Functional magnetic resonance imaging (FMRI) data were acquired in the first week and last week of the practice period. Results were compared with results of a control group who did not practice the task. We demonstrated that practice was beneficial for both working memory maintenance and manipulation processes but that these processes were supported by different neural changes. While maintenance trials showed increased activation (i.e., less deactivation) in default-mode regions after practice, manipulation trials experienced increased activation in the striatum. Changes were also observed in left ventrolateral prefrontal cortex (VLPFC), bilateral dorsolateral prefrontal cortex (DLPFC) and left superior parietal cortex (SPC). However, for bilateral DLPFC and left SPC, these changes were not specific to the practice group. These findings illustrate the importance of controlling for test-retest effects in training or intervention studies. Behavioral follow-up tests demonstrated that practice effects lasted over a 6-month period, but the absence of transfer effects indicated that the acquired skills were specific for the practiced working memory task.
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