Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles

Hemlata Kaur; Sunil Kumar; Pinki Vishwakarma; Monica Sharma; K K Saxena; Ashok Kumar

doi:10.1016/j.ejmech.2010.02.060

Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles

Eur J Med Chem. 2010 Jul;45(7):2777-83. doi: 10.1016/j.ejmech.2010.02.060. Epub 2010 Mar 7.

Authors

Hemlata Kaur¹, Sunil Kumar, Pinki Vishwakarma, Monica Sharma, K K Saxena, Ashok Kumar

Affiliation

¹ Medicinal Chemistry Division, Department of Pharmacology, L.L.R.M. Medical College, Garh Road, Meerut 250004, Uttar Pradesh, India.

PMID: 20392546
DOI: 10.1016/j.ejmech.2010.02.060

Abstract

A novel substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles (4a-j), (5a-j) and (6a-j) were synthesized and screened for their antipsychotic and anticonvulsant activities. It is concluded from the results compound 6j showed promising antipsychotic as well as anticonvulsant activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anticonvulsants / chemical synthesis
Anticonvulsants / chemistry
Anticonvulsants / pharmacology*
Anticonvulsants / toxicity
Antipsychotic Agents / chemical synthesis
Antipsychotic Agents / chemistry
Antipsychotic Agents / pharmacology*
Antipsychotic Agents / toxicity
Carbazoles / chemical synthesis*
Carbazoles / chemistry
Carbazoles / pharmacology*
Carbazoles / toxicity
Lethal Dose 50
Oxadiazoles / chemical synthesis*
Oxadiazoles / chemistry
Oxadiazoles / pharmacology*
Oxadiazoles / toxicity
Seizures / prevention & control
Thiadiazoles / chemical synthesis*
Thiadiazoles / chemistry
Thiadiazoles / pharmacology*
Thiadiazoles / toxicity

Substances

Anticonvulsants
Antipsychotic Agents
Carbazoles
Oxadiazoles
Thiadiazoles