Dasatinib induces long-term remission in imatinib-resistant Philadelphia chromosome-positive acute megakaryoblastic leukemia but fails to prevent development of central nervous system progression

MeSH terms

• Antineoplastic Agents / therapeutic use*
• Benzamides
• Central Nervous System Neoplasms / secondary*
• Dasatinib
• Drug Resistance, Neoplasm
• Humans
• Imatinib Mesylate
• Karyotyping
• Leukemia, Megakaryoblastic, Acute / drug therapy*
• Leukemia, Megakaryoblastic, Acute / genetics
• Leukemia, Megakaryoblastic, Acute / pathology
• Male
• Middle Aged
• Philadelphia Chromosome*
• Piperazines / therapeutic use*
• Pyrimidines / therapeutic use*
• Remission Induction
• Thiazoles / therapeutic use*