Iron-catalyzed N-alkylation of azoles via oxidation of C-H bond adjacent to an oxygen atom

Shiguang Pan; Jinhua Liu; Huanrong Li; Zhenyu Wang; Xingwei Guo; Zhiping Li

doi:10.1021/ol100670m

Iron-catalyzed N-alkylation of azoles via oxidation of C-H bond adjacent to an oxygen atom

Org Lett. 2010 May 7;12(9):1932-5. doi: 10.1021/ol100670m.

Authors

Shiguang Pan¹, Jinhua Liu, Huanrong Li, Zhenyu Wang, Xingwei Guo, Zhiping Li

Affiliation

¹ Department of Chemistry, Renmin University of China, Beijing 100872, China.

PMID: 20377238
DOI: 10.1021/ol100670m

Abstract

Azole derivatives were synthesized by iron-catalyzed oxidative reactions of azoles and ethers in good to excellent yields. A wide variety of azoles and ethers were selectively transformed into the corresponding oxidative coupling products under neutral reaction conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkylation
Azoles / chemistry*
Catalysis
Iron / chemistry*
Oxidation-Reduction
Oxygen / chemistry*

Substances

Azoles
Iron
Oxygen