Abstract
Two new triterpenes, 17(21)-hopene-6alpha,12beta-diol (1) and 17(21)-hopen-12beta-ol (2), the known 17(21)-hopen-6alpha-ol (zeorinin, 3), and two new biarylic dihydronaphthopyrones, aschernaphthopyrones A (4) and B (5), were isolated from the scale insect pathogenic fungus Aschersonia paraphysata BCC 11964. Hopene 1 and aschernaphthopyrone A (4) exhibited antimalarial activity with IC(50) values of 15 and 7.3 microM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology*
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Chlorocebus aethiops
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Drug Resistance, Multiple / drug effects
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Drug Screening Assays, Antitumor
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Female
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Humans
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Hypocreales / chemistry*
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Inhibitory Concentration 50
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Insecta / microbiology
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KB Cells
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Molecular Structure
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology*
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Plasmodium falciparum / drug effects*
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Pyrones / chemistry
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Pyrones / isolation & purification*
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Pyrones / pharmacology*
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Thailand
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
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Vero Cells
Substances
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17(21)-hopen-12beta-ol
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17(21)-hopene-6alpha,12beta-diol
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Antimalarials
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Naphthalenes
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Pyrones
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Triterpenes
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aschernaphthopyrone A
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aschernaphthopyrone B
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diploptene