Abstract
The present study examined the relationships among statin use, APOE genotype, and insulin resistance as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) in healthy older adults. APOE epsilon4- (i.e., not having an epsilon4 allele) statin users had higher HOMA-IR values compared with epsilon4+/statin users (p=0.0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aged
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Alzheimer Disease / epidemiology
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Alzheimer Disease / genetics
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Anticholesteremic Agents / therapeutic use*
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Apolipoprotein E4 / genetics*
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Dementia / epidemiology
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Dementia / genetics
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Diabetes Mellitus / epidemiology
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Female
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Genotype
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Homeostasis
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
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Hypercholesterolemia* / drug therapy
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Hypercholesterolemia* / epidemiology
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Hypercholesterolemia* / genetics
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Male
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Metabolic Syndrome / epidemiology*
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Prevalence
Substances
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Anticholesteremic Agents
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Apolipoprotein E4
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Hydroxymethylglutaryl-CoA Reductase Inhibitors