Kinetics of yttrium-ligand complexation monitored using hyperpolarized (89)Y as a model for gadolinium in contrast agents

J Am Chem Soc. 2010 Apr 14;132(14):5006-7. doi: 10.1021/ja1013954.

Abstract

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) enhances (89)Y spin magnetization by 3 to 4 orders of magnitude and provides a way to monitor yttrium-ligand complexation "on the fly" by means of (89)Y NMR. In this communication, we show an example of free yttrium Y(3+) being complexed with 1,4,7,10-tetrakis(acetamido)-1,4,7,10-tetraazacyclododecane (DOTAM) to form [Y(DOTAM)(H(2)O)](3+) as a model for gadolinium in contrast agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media / chemistry*
  • Gadolinium / chemistry*
  • Kinetics
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Organometallic Compounds / chemistry*
  • Yttrium / chemistry*

Substances

  • Contrast Media
  • Ligands
  • Organometallic Compounds
  • Yttrium
  • Gadolinium