Hyaluronan induces migration of multidrug-resistant lymphoma cell lines in vitro through Tiam1 activation by a PI3K-dependent mechanism

Leuk Res. 2010 Nov;34(11):1525-32. doi: 10.1016/j.leukres.2010.02.020. Epub 2010 Mar 17.

Abstract

Hyaluronan (HA) modulates multidrug resistance (MDR) as well as cell migration. Tiam1 is involved in cytoskeleton reorganization during tumor invasion. In this report we show the relationship among HA, Tiam1, migration and MDR in murine lymphoma cell lines. We observed that MDR cells presented higher migratory capacity towards HA in vitro as well as higher constitutive active Tiam1 expression than the sensitive cell line. Besides, HA treatment induced migration towards HA of MDR cell lines through Tiam1 activation by a PI3K-dependent mechanism, showing that disruption of HA signaling would be useful in treatment of MDR hematological malignancies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Movement / drug effects*
  • Drug Resistance, Multiple*
  • Guanine Nucleotide Exchange Factors / metabolism*
  • Hyaluronic Acid / pharmacology*
  • Lymphoma / drug therapy*
  • Lymphoma / pathology
  • Mice
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Signal Transduction
  • T-Lymphoma Invasion and Metastasis-inducing Protein 1

Substances

  • Guanine Nucleotide Exchange Factors
  • T-Lymphoma Invasion and Metastasis-inducing Protein 1
  • TIAM1 protein, human
  • Hyaluronic Acid
  • Phosphatidylinositol 3-Kinases