Synthesis and biodistribution of a new class of 99mTc-labeled fatty acid analogs for myocardial imaging

Int J Rad Appl Instrum B. 1991;18(2):215-26. doi: 10.1016/0883-2897(91)90082-v.

Abstract

A series of 99mTc-bis(aminoethanethiol)-fatty acid (99mTc-BAT-fatty acid) analogs were synthesized and evaluated as potential tracers of myocardial metabolism. The BAT-fatty acid precursors were prepared using a new synthetic route that avoids the use of strong reducing agents such as lithium aluminum hydride. Biodistribution studies of the no-carrier-added 99mTc-complexes were conducted in rats using [125I]IPPA as an internal standard. The myocardial uptake of the 99mTc-BAT-fatty acid analogs was significantly less than that of [125I]IPPA and indicates the 99mTc analogs are not suitable candidates for SPECT-based myocardial imaging studies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Fatty Acids / chemical synthesis*
  • Fatty Acids / pharmacokinetics
  • Heart / diagnostic imaging*
  • Male
  • Myocardium / metabolism*
  • Organotechnetium Compounds / chemical synthesis*
  • Organotechnetium Compounds / pharmacokinetics
  • Rats
  • Rats, Inbred Strains
  • Tissue Distribution
  • Tomography, Emission-Computed, Single-Photon*

Substances

  • Fatty Acids
  • Organotechnetium Compounds