Supramolecular biomaterials were prepared based on the formation of partial inclusion complexes between alpha-CD and poly(epsilon-caprolactone) (PCL). Enzyme-catalyzed degradation of these partial alpha-CD-PCL inclusion complexes was investigated at 37 degrees C in the presence of lipase from pancreas porcine. The biodegradation behaviors were monitored by weight loss measurement, (1)H NMR, XRD, GPC, DSC, and SEM. It was found that the formation of inclusion segments significantly accelerated the degradation of materials. A mechanism of enzymatic degradation for partial alpha-CD-PCL inclusion complexes was proposed. The present study provides a preliminary understanding for the biodegradation of the materials constructed by self-assembly between cyclodextrin and polymers.