Gukulenins A and B, cytotoxic tetraterpenoids from the marine sponge Phorbas gukulensis

Su Young Park; Hyukjae Choi; Hoosang Hwang; Heonjoong Kang; Jung-Rae Rho

doi:10.1021/np900606h

Gukulenins A and B, cytotoxic tetraterpenoids from the marine sponge Phorbas gukulensis

J Nat Prod. 2010 Apr 23;73(4):734-7. doi: 10.1021/np900606h.

Authors

Su Young Park¹, Hyukjae Choi, Hoosang Hwang, Heonjoong Kang, Jung-Rae Rho

Affiliation

¹ Department of Oceanography, Kunsan National University, Jeonbuk, 673-701, South Korea.

PMID: 20232859
DOI: 10.1021/np900606h

Abstract

Gukulenins A (1) and B (2), both having an unprecedented skeleton with a bis-tropolone moiety, were isolated from the Korean marine sponge Phorbas gukulensis. They exhibited significant cytotoxicity against human pharynx, stomach, colon, and renal cancer cell lines in the range 0.05-0.80 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Drug Screening Assays, Antitumor
HCT116 Cells
Humans
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera / chemistry*
Terpenes / chemistry
Terpenes / isolation & purification*
Terpenes / pharmacology*

Substances

Terpenes
gukulenin A
gukulenin B