A new protocol in photodynamic therapy: enhanced tumour cell death by combining two different photosensitizers

Photochem Photobiol Sci. 2010 Mar;9(3):295-7. doi: 10.1039/b9pp00153k. Epub 2010 Jan 27.

Abstract

The combined application of two photosensitisers (PSs), zinc(II) phthalocyanine (ZnPc) and the cationic porphyrin meso-tetrakis(4-N-methylpyridyl)porphine (T4MPyP), on HeLa cells produced an enhanced lethal effect relative to treatments with single PSs. Thus, the proper combination of PSs may constitute a new strategy to improve the efficacy of clinical photodynamic therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Death / drug effects*
  • Female
  • HeLa Cells
  • Humans
  • Indoles / chemistry
  • Indoles / therapeutic use*
  • Isoindoles
  • Photochemotherapy / methods*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / therapeutic use*
  • Porphyrins / chemistry
  • Porphyrins / therapeutic use*
  • Uterine Cervical Neoplasms / drug therapy*

Substances

  • Indoles
  • Isoindoles
  • Photosensitizing Agents
  • Porphyrins
  • porphine
  • phthalocyanine