Abstract
Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / toxicity
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Cell Line, Tumor
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Coordination Complexes / chemistry*
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Coordination Complexes / toxicity
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DNA / chemistry*
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DNA / metabolism
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Humans
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Imines / chemistry
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Iron / chemistry
Substances
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Antineoplastic Agents
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Coordination Complexes
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Imines
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DNA
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Iron