N400 and semantic categorization in schizophrenia

Biol Psychiatry. 1991 Mar 1;29(5):467-80. doi: 10.1016/0006-3223(91)90269-r.

Abstract

The N400 component of event-related potentials (ERPs) was investigated in medicated schizophrenic patients and normal controls in a semantic categorization task. The subjects' task was to indicate whether pairs of words were semantically related or unrelated. The ERPs to the unrelated second words of the pairs contained a negative component, N400, which was reduced and delayed in the patients. However, inspection of individual subjects' data indicated that N400 was abnormal only in a subgroup of schizophrenics. Abnormalities in the amplitude of N400 suggest impairments in semantic expectancies, whereas abnormalities in the latency of N400 suggest a delay in information processing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Electroencephalography*
  • Evoked Potentials
  • Humans
  • Male
  • Memory
  • Middle Aged
  • Schizophrenia / physiopathology*
  • Schizophrenic Language
  • Semantics*