Pd(II)-catalyzed olefination of sp3 C-H bonds

J Am Chem Soc. 2010 Mar 24;132(11):3680-1. doi: 10.1021/ja1010866.

Abstract

The first Pd(II)-catalyzed sp(3) C-H olefination reaction has been developed using N-arylamide directing groups. Following olefination, the resulting intermediates were found to undergo rapid 1,4-addition to give the corresponding gamma-lactams. Notably, this method was effective with substrates containing alpha-hydrogen atoms and could be applied to effect methylene C-H olefination of cyclopropane substrates.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkenes / chemistry*
  • Carbon / chemistry*
  • Catalysis
  • Hydrogen / chemistry*
  • Palladium / chemistry*

Substances

  • Alkenes
  • Palladium
  • Carbon
  • Hydrogen