JAK2 mutation and disease phenotype: a double L611V/V617F in cis mutation of JAK2 is associated with isolated erythrocytosis and increased activation of AKT and ERK1/2 rather than STAT5

Leukemia. 2010 May;24(5):1069-73. doi: 10.1038/leu.2010.23. Epub 2010 Feb 25.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amino Acid Sequence
  • Animals
  • B-Lymphocytes / metabolism
  • Base Sequence
  • Blotting, Western
  • Case-Control Studies
  • Cell Line
  • Colony-Forming Units Assay
  • Female
  • Genotype
  • Humans
  • Janus Kinase 2 / genetics*
  • Mice
  • Middle Aged
  • Mitogen-Activated Protein Kinase 1 / metabolism*
  • Mitogen-Activated Protein Kinase 3 / metabolism*
  • Molecular Sequence Data
  • Mutation / genetics*
  • Myeloproliferative Disorders / genetics
  • Myeloproliferative Disorders / metabolism
  • Myeloproliferative Disorders / pathology
  • Phenotype
  • Phosphorylation
  • Polycythemia / genetics*
  • Polycythemia / metabolism*
  • Polycythemia / pathology
  • Polymerase Chain Reaction
  • Proto-Oncogene Proteins c-akt / metabolism*
  • STAT5 Transcription Factor / metabolism*
  • Thrombosis / genetics
  • Thrombosis / metabolism
  • Thrombosis / pathology
  • Tyrosine / metabolism
  • Young Adult

Substances

  • STAT5 Transcription Factor
  • Tyrosine
  • JAK2 protein, human
  • Janus Kinase 2
  • Proto-Oncogene Proteins c-akt
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3