Synthesis and antitumor activity of 1-mesityl-3-(2-naphthoylmethano)-1H-imidazolium bromide

Xianghui Zeng; Xiaodong Yang; Yanli Zhang; Chen Qing; Hongbin Zhang

doi:10.1016/j.bmcl.2010.01.163

Synthesis and antitumor activity of 1-mesityl-3-(2-naphthoylmethano)-1H-imidazolium bromide

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1844-7. doi: 10.1016/j.bmcl.2010.01.163. Epub 2010 Feb 6.

Authors

Xianghui Zeng¹, Xiaodong Yang, Yanli Zhang, Chen Qing, Hongbin Zhang

Affiliation

¹ Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, PR China.

PMID: 20176485
DOI: 10.1016/j.bmcl.2010.01.163

Abstract

An imidazolium salt, 1-mesityl-3-(2-naphthoylmethano)-1H-imidazolium bromide (MNIB), has been investigated for its antitumor properties. In vitro studies demonstrate that MNIB is active against K562, SMMC-7721, EJ, AGZY, HEP-2, A549, HepG2, and Raji tumor cells, and can induce the G1 phase cell cycle arrest and apoptosis in K562 cells. Moreover, administration of MNIB significantly inhibited tumor growth in human non-small lung tumor (A549) xenografts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Cell Line, Tumor
Drug Screening Assays, Antitumor
G1 Phase / drug effects
Humans
Imidazoles / chemical synthesis*
Imidazoles / pharmacology*
Mice
Naphthalenes / chemical synthesis*
Naphthalenes / pharmacology*

Substances

1-mesityl-3-(2-naphthoylmethano)-1H-imidazolium
Antineoplastic Agents
Imidazoles
Naphthalenes