Capnocytophaga canimorsus infections in The Netherlands: a nationwide survey

Clin Microbiol Infect. 2011 Feb;17(2):312-5. doi: 10.1111/j.1469-0691.2010.03195.x.

Abstract

A retrospective nationwide survey on the occurrence of Capnocytophaga canimorsus and Capnocytopaga cynodegmi infections in The Netherlands over 3 years showed 32 cases, of which 31 were caused by C. canimorsus and one by an unspecified oxidase-positive Capnocytophaga strain. Twenty-eight patients had been diagnosed by blood culture, one by culture from both blood and cerebrospinal fluid (CSF), one by culture from a conjunctival swab, and two patients by 16S rRNA gene amplification by PCR directly from a blood or CSF specimen. The incidence rate was 0.67 infections per million population. Bacteraemia was found in 94% of the cases. The age range of patients was 38-80 years; 72% of them were male. Among 26 patients from whom clinical data were available, splenectomy was not reported, but alcoholism was reported in five. Nine patients (35%) had been admitted to the intensive-care unit, and three patients (13%) died. The mortality rate was much lower than observed in previous studies.

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Bacteriological Techniques / methods
  • Blood / microbiology
  • Capnocytophaga / classification
  • Capnocytophaga / isolation & purification*
  • Cerebrospinal Fluid / microbiology
  • Conjunctiva / microbiology
  • Female
  • Gram-Negative Bacterial Infections / epidemiology*
  • Gram-Negative Bacterial Infections / microbiology*
  • Gram-Negative Bacterial Infections / mortality
  • Hospitalization / statistics & numerical data
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Netherlands / epidemiology
  • Polymerase Chain Reaction / methods
  • RNA, Bacterial / genetics
  • RNA, Ribosomal, 16S / genetics
  • Retrospective Studies
  • Sex Distribution

Substances

  • RNA, Bacterial
  • RNA, Ribosomal, 16S