DNA (6-4) photolyases reduce Dewar isomers for isomerization into (6-4) lesions

Andreas F Glas; Emine Kaya; Sabine Schneider; Korbinian Heil; Danila Fazio; Melanie J Maul; Thomas Carell

doi:10.1021/ja910917f

DNA (6-4) photolyases reduce Dewar isomers for isomerization into (6-4) lesions

J Am Chem Soc. 2010 Mar 17;132(10):3254-5. doi: 10.1021/ja910917f.

Authors

Andreas F Glas¹, Emine Kaya, Sabine Schneider, Korbinian Heil, Danila Fazio, Melanie J Maul, Thomas Carell

Affiliation

¹ Center for Integrative Protein Science, Department of Chemistry and Biochemistry, Ludwig-Maximilians University Munich, Butenandtstr. 5-13, 81377 Munich, Germany.

PMID: 20166732
DOI: 10.1021/ja910917f

Abstract

Repair of the Dewar valence isomers by (6-4) photolyases proceeds via an enzyme catalyzed ring-opening reaction of the Dewar lesion to the (6-4) photoproduct.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytosine / analogs & derivatives
DNA Damage*
DNA Repair
DNA, Single-Stranded / chemistry
DNA, Single-Stranded / radiation effects
Deoxyribodipyrimidine Photo-Lyase / chemistry*
Isomerism
Oligonucleotides / chemistry*
Pyrimidine Dimers / chemistry
Thymidine / analogs & derivatives

Substances

DNA, Single-Stranded
Oligonucleotides
Pyrimidine Dimers
Cytosine
Deoxyribodipyrimidine Photo-Lyase
Thymidine