Circulating maternal testosterone concentrations at 18 weeks of gestation predict circulating levels of antimüllerian hormone in adolescence: a prospective cohort study

Roger Hart; Deborah M Sloboda; Dorota A Doherty; Robert J Norman; Helen C Atkinson; John P Newnham; Jan E Dickinson; Martha Hickey

doi:10.1016/j.fertnstert.2009.12.060

Circulating maternal testosterone concentrations at 18 weeks of gestation predict circulating levels of antimüllerian hormone in adolescence: a prospective cohort study

Fertil Steril. 2010 Sep;94(4):1544-1547. doi: 10.1016/j.fertnstert.2009.12.060. Epub 2010 Feb 13.

Authors

Roger Hart¹, Deborah M Sloboda², Dorota A Doherty³, Robert J Norman⁴, Helen C Atkinson⁵, John P Newnham³, Jan E Dickinson⁵, Martha Hickey⁵

Affiliations

¹ School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia. Electronic address: roger.hart@uwa.edu.au.
² Liggins Institute, University of Auckland, and the National Research Centre for Growth and Development, Auckland, New Zealand.
³ School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia; Women and Infants Research Foundation, King Edward Memorial Hospital, Perth, Western Australia, Australia.
⁴ Research Centre for Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia.
⁵ School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.

PMID: 20153853
DOI: 10.1016/j.fertnstert.2009.12.060

Abstract

This prospective study was established to determine the impact of maternal circulating androgen levels during normal pregnancy on ovarian function, as determined by early follicular phase antimüllerian hormone (AMH) levels, inhibin B levels, and antral follicle count (AFC) in 244 female offspring in adolescence. Maternal circulating total testosterone levels at 18 weeks' gestation were statistically significantly correlated with early follicular-phase circulating AMH levels in female adolescent offspring, but no other statistically significant correlations were determined among the maternal androgens at 18 or 34 weeks of gestation and the markers of adolescent ovarian function.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Anti-Mullerian Hormone / blood*
Cohort Studies
Female
Gestational Age
Humans
Maternal-Fetal Exchange / physiology
Mothers
Polycystic Ovary Syndrome / blood*
Polycystic Ovary Syndrome / diagnosis*
Pregnancy
Pregnancy Trimester, Second / blood*
Prenatal Exposure Delayed Effects / blood*
Prognosis
Prospective Studies
Testosterone / blood*

Substances

Testosterone
Anti-Mullerian Hormone