Pediatric reference intervals for immunoglobulin G and its subclasses with Siemens immunonephelometric assays

Nathalie Lepage; Shih-Han S Huang; Ed Nieuwenhuys; Guido Filler

doi:10.1016/j.clinbiochem.2010.02.003

Pediatric reference intervals for immunoglobulin G and its subclasses with Siemens immunonephelometric assays

Clin Biochem. 2010 May;43(7-8):694-6. doi: 10.1016/j.clinbiochem.2010.02.003. Epub 2010 Feb 12.

Authors

Nathalie Lepage¹, Shih-Han S Huang, Ed Nieuwenhuys, Guido Filler

Affiliation

¹ Department of Pathology and Laboratory Medicine, Children's Hospital of Eastern Ontario, Ottawa, Canada.

PMID: 20153742
DOI: 10.1016/j.clinbiochem.2010.02.003

Abstract

Objective: To determine the pediatric reference intervals for the Dade Behring IgG subclass reagents.

Design and methods: Blood samples of healthy children and adolescents were analyzed to determine the level of immunoglobulin G (IgG) and the IgG subclass using the reagents of Dade Behring Marburg GmbH.

Results: The reference intervals categorized by age were reported from a total of 436 samples. There was an excellent correlation between the total IgG and the sum of the IgG subclasses.

Conclusions: Our data provide the missing pediatric reference intervals and enable the use of the Dade Behring nephelometric IgG subclass reagents in children and adolescents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Child, Preschool
Female
Humans
Immunoglobulin G / analysis*
Infant
Male
Nephelometry and Turbidimetry / methods*
Nephelometry and Turbidimetry / standards
Reference Values

Substances

Immunoglobulin G