Abstract
RNAi is essential for pericentromeric heterochromatic formation in S. pombe, and although Dcr1, the initiator protein of this process, has been biochemically well described, its subcellular localization has remained elusive. In this issue of Developmental Cell, Emmerth et al. now show that Dcr1 is dynamically shuttling between nucleus and cytoplasm, adding new insight into the subcellular mechanics of RNAi.
(c) 2010 Elsevier Inc. All rights reserved.
MeSH terms
-
Active Transport, Cell Nucleus / genetics
-
Animals
-
Cell Nucleus / genetics*
-
Cell Nucleus / metabolism
-
Cytoplasm / genetics
-
Cytoplasm / metabolism
-
Heterochromatin / genetics
-
Humans
-
Intracellular Signaling Peptides and Proteins / genetics
-
Nuclear Pore / genetics
-
Nuclear Pore / metabolism
-
Protein Transport
-
RNA Interference / physiology*
-
Ribonuclease III / genetics*
-
Ribonuclease III / metabolism
-
Schizosaccharomyces / genetics*
-
Schizosaccharomyces / metabolism
Substances
-
Gid8 protein, S cerevisiae
-
Heterochromatin
-
Intracellular Signaling Peptides and Proteins
-
Ribonuclease III