Corifollitropin alfa in a long GnRH agonist protocol: proof of concept trial

Fertil Steril. 2010 Oct;94(5):1922-4. doi: 10.1016/j.fertnstert.2009.12.070. Epub 2010 Feb 10.

Abstract

Fifty healthy women, aged 18-39 years with no known risk of ovarian hyperstimulation were treated with 100 or 150 μg corifollitropin alfa (dependent on body weight) in a long GnRH agonist protocol. At these doses, corifollitropin alfa initiated and supported growth of a large cohort of follicles during the first week of ovarian stimulation.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Cell Count
  • Chorionic Gonadotropin / pharmacology
  • Cohort Studies
  • Dose-Response Relationship, Drug
  • Female
  • Fertilization in Vitro*
  • Follicle Stimulating Hormone / pharmacology
  • Follicle Stimulating Hormone, Human / pharmacology*
  • Gonadotropin-Releasing Hormone / agonists*
  • Humans
  • Inhibins / metabolism
  • Oocyte Retrieval
  • Oocytes / cytology
  • Ovarian Follicle / cytology
  • Ovarian Follicle / drug effects*
  • Ovarian Follicle / metabolism
  • Ovulation Induction / methods*
  • Pilot Projects
  • Pregnancy
  • Pregnancy Rate
  • Recombinant Proteins / pharmacology*
  • Young Adult

Substances

  • Chorionic Gonadotropin
  • Follicle Stimulating Hormone, Human
  • Recombinant Proteins
  • follicle stimulating hormone, human, with HCG C-terminal peptide
  • inhibin B
  • Gonadotropin-Releasing Hormone
  • Inhibins
  • Follicle Stimulating Hormone