Shedding light on sperm pHertility

Harvey M Florman; Melissa K Jungnickel; Keith A Sutton

doi:10.1016/j.cell.2010.01.035

Shedding light on sperm pHertility

Cell. 2010 Feb 5;140(3):310-2. doi: 10.1016/j.cell.2010.01.035.

Authors

Harvey M Florman¹, Melissa K Jungnickel, Keith A Sutton

Affiliation

¹ Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA. harvey.florman@umassmed.edu

PMID: 20144756
DOI: 10.1016/j.cell.2010.01.035

Abstract

The acquisition of fertilization capacity by sperm is regulated by intracellular pH (pH(i)), but the transport pathways that regulate pH(i) are not well understood. Lishko et al. (2010) now report that Hv1, the voltage-sensitive proton channel, is present in human sperm and is an important regulator of the functional maturation of sperm.

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MeSH terms

Animals
Humans
Hydrogen-Ion Concentration
Male
Membrane Potentials
Mice
Sperm Capacitation*
Spermatozoa / cytology
Spermatozoa / metabolism