Abstract
A simple and efficient palladium-catalyzed domino reaction for the synthesis of a series of C1-substituted tetrahydro-beta-carbolines is described. This domino process involves a Heck reaction at the indole 2-position of a halogenated tryptamine precursor, followed by intramolecular aza-Michael addition.
MeSH terms
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Aza Compounds / chemistry*
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Carbolines / chemical synthesis*
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Carbolines / chemistry
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Catalysis
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Combinatorial Chemistry Techniques
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Palladium / chemistry
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Stereoisomerism
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Tryptamines / chemistry*
Substances
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Aza Compounds
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Carbolines
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Tryptamines
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Palladium