Abstract
In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin. In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum. Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use*
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Cell Cycle / drug effects
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DNA Replication / drug effects
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Diterpenes / therapeutic use*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / pharmacology
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Drugs, Chinese Herbal / therapeutic use*
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Ear
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Edema / chemically induced
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Edema / drug therapy
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Edema / immunology
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Female
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Interleukin-2 / antagonists & inhibitors*
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Interleukin-2 / blood
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Isodon / chemistry*
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Male
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Mice
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Mice, Inbred BALB C
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Phytotherapy
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Plant Components, Aerial
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RNA, Messenger / metabolism
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T-Lymphocytes / drug effects*
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T-Lymphocytes / metabolism
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Xylenes
Substances
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Anti-Inflammatory Agents
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Diterpenes
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Drugs, Chinese Herbal
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Interleukin-2
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RNA, Messenger
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Xylenes
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nodosin