Benzotetramisole-catalyzed dynamic kinetic resolution of azlactones

Org Lett. 2010 Feb 19;12(4):892-5. doi: 10.1021/ol902969j.

Abstract

Enantioselective acyl transfer catalyst benzotetramisole (BTM) has been found to promote dynamic kinetic resolution of azlactones providing di(1-naphthyl)methyl esters of alpha-amino acids with up to 96% ee.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemical synthesis
  • Amino Acids / chemistry*
  • Aza Compounds / chemical synthesis
  • Aza Compounds / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Esters
  • Kinetics
  • Lactones / chemical synthesis
  • Lactones / chemistry*
  • Molecular Structure
  • Stereoisomerism
  • Tetramisole / analogs & derivatives*
  • Tetramisole / chemistry

Substances

  • Amino Acids
  • Aza Compounds
  • Esters
  • Lactones
  • benzotetramisole
  • Tetramisole