Two distinct loci on the short arm of chromosome 16 are involved in myeloid leukemia

J W Wessels; P Mollevanger; J G Dauwerse; F H Cluitmans; M H Breuning; G C Beverstock

Two distinct loci on the short arm of chromosome 16 are involved in myeloid leukemia

Blood. 1991 Apr 1;77(7):1555-9.

Authors

J W Wessels¹, P Mollevanger, J G Dauwerse, F H Cluitmans, M H Breuning, G C Beverstock

Affiliation

¹ Department of Human Genetics, State University Hospital, Leiden, The Netherlands.

PMID: 2009371

Abstract

We report a case of acute nonlymphocytic leukemia (ANLL) M5 with the characteristic t(8;16)(p11;p13). The breakpoint in the short arm was regionally localized using nonradioactive in situ hybridization with a series of cosmids of chromosome 16. The results show that a difference exists between the breakpoint in chromosome 16(p13) in this t(8;16) and the breakpoint involved in the short arm in the characteristic inversion 16 (p13;q22)) that occurs in ANLL M4eo. Two different loci appear to be involved in these chromosomal rearrangements.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bone Marrow / pathology*
Cells, Cultured
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 16*
Chromosomes, Human, Pair 8*
Female
Humans
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology
Metaphase
Plasmids
Translocation, Genetic*