Effects of task relevance and attention on P3 in schizophrenic patients

Schizophr Res. 1991 Jan-Feb;4(1):11-21. doi: 10.1016/0920-9964(91)90005-c.

Abstract

The P3 component of the event-related potentials (ERPs) to auditory task-relevant and task-irrelevant stimuli in 'Attend Auditory' (i.e., reaction time task) and 'Attend Visual' (i.e., when the auditory stimuli were being ignored) conditions was investigated in 13 RDC/DSM-III diagnosed schizophrenic patients. ERPs were recorded from Fz, Cz, and Pz. Compared to controls, schizophrenics had a significantly smaller P3 in the Attend Auditory than in the Attend Visual condition and to the task-relevant than to the task-irrelevant stimuli. Furthermore, the patients' P3 response to the most salient task-irrelevant stimuli in the Attend visual condition was normal. The results are discussed as suggesting that schizophrenics either allocate relatively more resources to task-irrelevant than task-relevant stimuli or that they fail to habituate to task-irrelevant stimuli.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Arousal / physiology*
  • Attention / physiology*
  • Cerebral Cortex / physiopathology
  • Color Perception / physiology
  • Electroencephalography / instrumentation
  • Evoked Potentials, Auditory / physiology*
  • Female
  • Humans
  • Male
  • Pitch Discrimination / physiology
  • Psychomotor Performance / physiology
  • Schizophrenia / diagnosis*
  • Schizophrenia / physiopathology
  • Schizophrenic Psychology*
  • Signal Processing, Computer-Assisted / instrumentation