[Natural history of multiple sclerosis]

Abstract

Multiple sclerosis (MS) is the most frequent chronic, disabling neurological disease in young adults in France. Descriptions of the natural history of large cohorts have provided extensive information about the overall course and prognosis of MS, but individual prognosis remains a major challenge for researchers. Recent studies suggest that the clinical phenotype of MS is mostly age-related and that relapses play a minimal role in the long-term accumulation of disability.