Hepatitis C infection is a global burden disease. Its relationship to chronic hepatitis, cirrhosis and hepatocellular carcinoma has been demonstrated, and at the current moment in USA and Europe is one of the major causes for liver transplantation. In Latin America, seroprevalence for HCV is between 1-2%. Risk groups are well-known: persons that have received blood products, drug addicts, health-workers, sexual workers, convicts, those with tattoo or piercing, as well as newborns from women positive for HCV. Genotype 1 is the more prevalent (> 80%) in Latinamerica, although genotypes 2, 3 and 4 have been found. In Peru, prevalence is low, around 1%, being found more frequently in the jungle region. Risk groups demonstrated in Perú are persons that received transfusion, patients in hemodyalisis, health-workers (in special those that work with blood products), and drugaddicts especially those with cocaine aspiration. Genotype 1 is the more prevalent, although few studies have been done. It is urgent to do more epidemiological studies related to this infection to know the real situation of this disease and its consequences in order to establish better health strategies.