Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes

Chem Commun (Camb). 2010 Jan 28;46(4):625-7. doi: 10.1039/b918964e. Epub 2009 Nov 20.

Abstract

Guanidino-modified phthalocyanines are evaluated in vitro (polymerase-stop assays and FRET) and in cultured cells as G4-DNA ligands and modulators of gene transcription.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Membrane Permeability
  • DNA / genetics
  • G-Quadruplexes / drug effects*
  • Guanidine / chemistry
  • Guanidine / pharmacology*
  • HeLa Cells
  • Humans
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Isoindoles
  • Mice
  • NIH 3T3 Cells
  • Proto-Oncogene Proteins p21(ras) / genetics*
  • Transcription, Genetic / drug effects*

Substances

  • Antineoplastic Agents
  • Indoles
  • Isoindoles
  • DNA
  • Proto-Oncogene Proteins p21(ras)
  • Guanidine
  • phthalocyanine