Abstract
The molecular epidemiology of CVA16 in China between 1999 and 2008 reflects a pattern of endemic cocirculation of clusters B1a and B1b within subgenotype B1 viruses. The annual evolution rate of CVA16 was estimated as approximately 0.91 x 10(-2) substitutions per synonymous nucleotide/year and is slightly lower than that of HEV71.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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China / epidemiology
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Cluster Analysis
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Endemic Diseases*
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Enterovirus A, Human / classification*
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Enterovirus A, Human / genetics*
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Enterovirus A, Human / isolation & purification
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Evolution, Molecular*
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Hand, Foot and Mouth Disease / epidemiology*
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Hand, Foot and Mouth Disease / virology*
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Humans
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Molecular Sequence Data
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Phylogeny
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Point Mutation
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Polymorphism, Genetic*
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RNA, Viral / genetics
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Sequence Analysis, DNA
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Sequence Homology
Associated data
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GENBANK/GQ429220
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GENBANK/GQ429221
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GENBANK/GQ429222
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GENBANK/GQ429223
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GENBANK/GQ429224
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