New pH-dependent complexes, from mononuclear Pd(II) monomer to heteronuclear [Pd(II),K(I)]Polymer: DNA cleavage and cytotoxicity in vitro

Eur J Med Chem. 2010 Mar;45(3):1034-41. doi: 10.1016/j.ejmech.2009.11.048. Epub 2009 Dec 2.

Abstract

Two novel complexes, namely, [Pd(pdc)(2)].(dmp).6H(2)O (1) and [Pd(pdc)(2)K(H(2)O)(5).3H(2)O]n (2) [H(2)pdc=pyridine-2,3-dicarboxylate acid, dmp=2,9-Dimethyl-1,10-phenanthroline] were synthesized and characterized as pH-dependent products. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR 322 plasmid DNA. Values of IC(50) calculated for complexes 1 and 2 show that the two complexes exhibit good cytotoxic activity against different cell lines tested in general, especially more effective against HL-60 and A2780(cisR) cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Cell Line, Tumor
  • Crystallography, X-Ray
  • DNA Cleavage
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Hydrogen Bonding
  • Hydrogen-Ion Concentration
  • Inhibitory Concentration 50
  • Macromolecular Substances
  • Magnetic Resonance Spectroscopy
  • Models, Molecular*
  • Molecular Structure
  • Organoplatinum Compounds / chemistry*
  • Palladium / chemistry*

Substances

  • Antineoplastic Agents
  • Macromolecular Substances
  • Organoplatinum Compounds
  • Palladium