Daptomycin use in a neonate: serum level monitoring and outcome

Am J Perinatol. 2010 May;27(5):421-4. doi: 10.1055/s-0029-1243370. Epub 2009 Dec 10.

Abstract

We present a case of successfully treated persistent bacteremia due to Gram-positive bacteria with daptomycin in a preterm neonate. Daptomycin was given at higher doses (6 mg/kg/dose) and shorter intervals (every 12 hours) than those recommended for adults with no adverse events. Peak and trough serum concentrations of daptomycin were 27.3 and 11.6 μg/mL [DOSAGE ERROR CORRECTED] at day 4 as well as 22.9 and 7.9 μg/mL [DOSAGE ERROR CORRECTED]at day 11 after initiation of treatment, respectively.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / blood*
  • Daptomycin / administration & dosage*
  • Daptomycin / blood*
  • Female
  • Gram-Positive Bacterial Infections / drug therapy*
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Daptomycin