Two cases of bovine male pseudohermaphrodites with different endocrinological and pathological findings

J Vet Med Sci. 2010 Apr;72(4):507-10. doi: 10.1292/jvms.09-0403. Epub 2009 Dec 15.

Abstract

Two cases of bovine male pseudohermaphrodites (PH) were subjected for clinical investigation with transrectal ultrasonography, endocrinology with adoption of hCG-stimulation test, cytogenetics with analysis of sex chromosome and Y-specific DNA, and finally histological examination. Results were compared with normal calves. Case 1 was a 10-month-old calf with XX/XY chimeras, showing elevation of testosterone (T) levels, but no change in progesterone (P(4)) after hCG test, and possessed atrophied testes in the cavitas pelvis. Case 2 was an 18-month-old calf with SRY positive-XY chromosome, showing lower level of plasma T and P(4) after hCG test, and possessed atrophied testes and undifferentiated genital ducts. Both cases possessed female-like external genitalia with similar pathological findings, however endocrinological and cytogenetical aspects were different each other.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Cattle / anatomy & histology*
  • Cattle Diseases / genetics*
  • Cattle Diseases / pathology*
  • DNA / genetics
  • DNA Primers
  • Disorders of Sex Development / genetics*
  • Disorders of Sex Development / pathology
  • Disorders of Sex Development / veterinary*
  • Female
  • Genes, sry
  • Genitalia, Female / anatomy & histology
  • Leydig Cells / pathology
  • Male
  • Polymerase Chain Reaction
  • Seminiferous Tubules / anatomy & histology
  • Seminiferous Tubules / pathology
  • Spermatogenesis
  • Y Chromosome

Substances

  • DNA Primers
  • DNA